Bilateral activation of the prefrontal cortex after strategic semantic cognitive training

Eliane C. Miotto, Cary R. Savage, Jonathan J. Evans, Barbara A. Wilson, M. G.M. Martins, Suzan Iaki, Edson Amaro

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


The prefrontal cortex (PFC) has been implicated in the ability to apply semantic organizational strategies during verbal encoding and episodic learning. However, there has been no direct evidence demonstrating which specific areas in the PFC are engaged after cognitive training using semantic organizational strategies in healthy adult human subjects. In this study, we investigated the effects of semantic strategic training on brain activity and changes in behavioral performance, after cognitive training, using functional MRI (fMRI). There was a significant activation in bilateral dorsolateral prefrontal (DLPF) and orbitofrontal (OFC) areas after cognitive training. These results demonstrate the engagement of bilateral DLPF and OFC cortex during strategic memory processes, particularly when mobilization and effort of effective use of strategies are required. The functional adaptations observed here may also shed light on some of the processes underlying recovery with cognitive rehabilitation in patient populations with brain injury.

Original languageEnglish (US)
Pages (from-to)288-295
Number of pages8
JournalHuman Brain Mapping
Issue number4
StatePublished - Apr 2006
Externally publishedYes


  • Cognitive training
  • Prefrontal
  • Strategy
  • fMRI

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


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