Bilateral Internuclear Ophthalmoplegia Reversed by Naloxone

Matthew Rizzo, James Corbett

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We encountered an apparent bilateral internuclear ophthalmoplegia (INO) in a stuporous patient who used narcotics and benzodiazepines and had taken phenytoin sodium for drug-withdrawal seizures. The INO was promptly reversed by administration of the narcotic antagonist naloxone, which binds opiate receptors. This suggests the INO resulted from a specific toxic effect of narcotics, but opiate receptors have not been anatomically demonstrated within the medial longitudinal fasciculus or associated structures. Stimulation of inhibitory GABA-ergic (α-aminobutyric acid) vestibulo-ocular fibers may have been related to INO in this case.

Original languageEnglish (US)
Pages (from-to)242-243
Number of pages2
JournalArchives of Neurology
Issue number4
StatePublished - Apr 1983
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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