Abstract
The sequence specificity and structural aspects of the mode of interaction of the antitumor drug actinomycin D (AMD) with single-stranded DNA were studied by fluorescence, absorption and NMR spectroscopy, calorimetry, ultrasonic velocity and density measurements, and molecular modeling. The binding is length and sequence dependent, with the tetranucleotide motif TAGT showing the highest affinity. A 'hemi- intercalation' model for the interaction is proposed.
Original language | English (US) |
---|---|
Pages (from-to) | 661-667 |
Number of pages | 7 |
Journal | Nucleosides and Nucleotides |
Volume | 16 |
Issue number | 5-6 |
DOIs | |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Genetics