Bioactive natural products from Lysobacter

Yunxuan Xie, Stephen Wright, Yuemao Shen, Liangcheng Du

Research output: Contribution to journalReview article

100 Scopus citations

Abstract

Covering: up to March 2012 The gliding Gram-negative Lysobacter bacteria are emerging as a promising source of new bioactive natural products. These ubiquitous freshwater and soil microorganisms are fast growing, simple to use and maintain, and genetically amenable for biosynthetic engineering. This Highlight reviews a group of biologically active and structurally distinct natural products from the genus Lysobacter, with a focus on their biosyntheses. Although Lysobacter sp. are known as prolific producers of bioactive natural products, detailed molecular mechanistic studies of their enzymatic assembly have been surprisingly scarce. We hope to provide a snapshot of the important work done on the lysobacterial natural products and to provide useful information for future biosynthetic engineering of novel antibiotics in Lysobacter.

Original languageEnglish (US)
Pages (from-to)1277-1287
Number of pages11
JournalNatural Product Reports
Volume29
Issue number11
DOIs
StatePublished - Nov 2012

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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