Bioadhesives for intraocular use

Eyal Margalit, Gildo Y. Fujii, James C. Lai, Puneet Gupta, Shih Jen Chen, Jeng Shyong Shyu, Duke V. Piyathaisere, James D. Weiland, Eugene De Juan, Mark S. Humayun

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background/Purpose: A safe, effective adhesive could be useful in the management of retinal holes or tears and selected complicated retinal detachments, as well as for attaching a small electronic device (retinal prosthesis) to the retina. In this study, we examined nine commercially available compounds for their suitability as intraocular adhesives. Methods: The following materials were studied: commercial fibrin sealant, autologous fibrin, Cell-Tak, three photocurable glues, and three different polyethylene glycol hydrogels. An electronic strain gauge measured the adherence forces between different glues and the retina. The stability of hydrogels at body temperature and the impermeability of the hydrogel adhesive to dextran blue were examined. Long-term biocompatibility testing of the most promising glues in terms of adhesive force, consistency, and short-term safety (hydrogels) were done in rabbits. Funduscopy, electroretinogram, and histology of the retina were performed. Results: Hydrogels had 2 to 39 times more adhesive force (measured in mN) than the other glues tested. They liquefied at body temperature after 3 days to a few months. Hydrogels were impermeable to dextran blue. One type of hydrogel proved to be nontoxic to the retina. Conclusions: Hydrogels proved to be superior for intraocular use in terms of consistency, adhesiveness, stability, impermeability, and safety.

Original languageEnglish (US)
Pages (from-to)469-477
Number of pages9
Issue number5
StatePublished - 2000


  • Adhesive
  • Biocompatible
  • Hydrogel
  • Retinal detachment
  • Retinal prosthesis
  • Retinopexy

ASJC Scopus subject areas

  • Ophthalmology


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