TY - GEN
T1 - Biochemical and molecular analysis of the biosynthesis of fumonisins
AU - Du, Liangcheng
AU - Yu, Fengan
AU - Zhu, Xiangcheng
AU - Zaleta-Rivera, Kathia
AU - Bojja, Ravi S.
AU - Ding, Yousong
AU - Yi, Han
AU - Wang, Qiaomei
PY - 2007
Y1 - 2007
N2 - Fumonisins are mycotoxins produced by several widespread fungal pathogens of corn. Ingestion of fumonisin contaminated food and feeds causes several fatal diseases in livestock and is associated with esophageal cancer and neural tube defects in humans. In the recent years, fumonisin research has become one of the most active areas in fungal secondary metabolism. The gene cluster (FUM) required for fumonisin biosynthesis in Fusarium verticillioides has been cloned. The FUM genes are predicted to encode various fascinating enzymes, including a seven-domain iterative modular polyketide synthase (PKS), the first example of a fusion protein between the two subunits of serine palmitoyltransferase, a naturally fused cytochrome P450 monooxygenase and reductase, and a "stand-alone" nonribosomal peptide synthetase complex. This review highlights the progress in the studies of the molecular mechanism for fumonisin biosynthesis.
AB - Fumonisins are mycotoxins produced by several widespread fungal pathogens of corn. Ingestion of fumonisin contaminated food and feeds causes several fatal diseases in livestock and is associated with esophageal cancer and neural tube defects in humans. In the recent years, fumonisin research has become one of the most active areas in fungal secondary metabolism. The gene cluster (FUM) required for fumonisin biosynthesis in Fusarium verticillioides has been cloned. The FUM genes are predicted to encode various fascinating enzymes, including a seven-domain iterative modular polyketide synthase (PKS), the first example of a fusion protein between the two subunits of serine palmitoyltransferase, a naturally fused cytochrome P450 monooxygenase and reductase, and a "stand-alone" nonribosomal peptide synthetase complex. This review highlights the progress in the studies of the molecular mechanism for fumonisin biosynthesis.
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U2 - 10.1021/bk-2007-0955.ch006
DO - 10.1021/bk-2007-0955.ch006
M3 - Conference contribution
AN - SCOPUS:36749005080
SN - 0841239789
SN - 9780841239784
T3 - ACS Symposium Series
SP - 81
EP - 96
BT - Polyketides Biosynthesis, Biological Activity, and Genetic Engineering
PB - American Chemical Society
ER -