Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery

Timothy M. Brenza, Benjamin W. Schlichtmann, Biju Bhargavan, Julia E. Vela Ramirez, Rainie D. Nelson, Matthew G. Panthani, Jo Ellyn M. McMillan, Balaraman Kalyanaraman, Howard E. Gendelman, Vellareddy Anantharam, Anumantha G. Kanthasamy, Surya K. Mallapragada, Balaji Narasimhan, Georgette D. Kanmogne

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

An urgent need to deliver therapeutics across the blood–brain barrier (BBB) underlies a paucity of effective therapies currently available for treatment of degenerative, infectious, traumatic, chemical, and metabolic disorders of the nervous system. With an eye toward achieving this goal, an in vitro BBB model was employed to simulate biodegradable polyanhydride nanoparticle-based drug delivery to the brain. Using a combination of confocal microscopy, flow cytometry, and high performance liquid chromatography, we examined the potential of polyanhydride nanoparticles containing the anti-oxidant, mito-apocynin, to be internalized and then transferred from monocytes to human brain microvascular endothelial cells. The efficacy of this nanoparticle-based delivery platform was demonstrated by neuronal protection against oxidative stress. Taken together, this polyanhydride nanoparticle-based delivery system holds promise for enhancing neuroprotection by facilitating drug transport across the BBB.

Original languageEnglish (US)
Pages (from-to)2881-2890
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume106
Issue number11
DOIs
StatePublished - Nov 2018

Keywords

  • blood–brain barrier
  • cell-mediated transcytosis
  • mito-apocynin
  • nanoparticles
  • polyanhydrides

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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  • Cite this

    Brenza, T. M., Schlichtmann, B. W., Bhargavan, B., Vela Ramirez, J. E., Nelson, R. D., Panthani, M. G., McMillan, J. E. M., Kalyanaraman, B., Gendelman, H. E., Anantharam, V., Kanthasamy, A. G., Mallapragada, S. K., Narasimhan, B., & Kanmogne, G. D. (2018). Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. Journal of Biomedical Materials Research - Part A, 106(11), 2881-2890. https://doi.org/10.1002/jbm.a.36477