Bioengineering strategies for the treatment of type i diabetes

Xiaoyan Liu, Xiaowei Li, Ning Zhang, Zhanzheng Zhao, Xuejun Wen

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Diabetes mellitus, the third most common disease in the world, is a chronic metabolic disorder caused by a failure of insulin production and/or an inability to respond to insulin. Specifically, type 1 diabetes is a disease resulted by the autoimmune destruction of a patient's β-cell population within the pancreatic islets of Langerhans. The current primary treatment for type 1 diabetes is daily multiple insulin injections. However, this treatment cannot provide sustained physiological release, and the insulin amount is not finely tuned to glycemia. Pancreatic transplants or islet transplants would be the preferred treatment method but the lack of donor tissue and immunoincompatibility has been shown to be a roadblock to their widespread use. Bioengineering strategies are poised to combat these challenges. In this review, bioengineering approaches for the treatment of type 1 diabetes, including insulin controlled release systems, strategies for immunoisolation of transplanted islets, and cell-based therapies, such as β-cells and stem cells, are discussed.

Original languageEnglish (US)
Pages (from-to)581-601
Number of pages21
JournalJournal of Biomedical Nanotechnology
Volume12
Issue number4
DOIs
StatePublished - Apr 2016

Keywords

  • Biomaterials
  • Immunoisolation
  • Islets
  • Type 1 Diabetes
  • β-Cells

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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