Biogenesis of cytochrome c oxidase

Oleh Khalimonchuk, Gerhard Rödel

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations

Abstract

Cytochrome c oxidase (COX), the terminal enzyme of electron transport chains in some prokaryotes and in mitochondria, has been characterized in detail over many years. Recently, a number of new data on structural and functional aspects as well as on COX biogenesis emerged. COX biogenesis includes a variety of steps starting from translation to the formation of the mature complex. Each step involves a set of specific factors that assist translation of subunits, their translocation across membranes, insertion of essential cofactors, assembly and final maturation of the enzyme. In this review, we focus on the organization and biogenesis of COX.

Original languageEnglish (US)
Pages (from-to)363-388
Number of pages26
JournalMitochondrion
Volume5
Issue number6
DOIs
StatePublished - Dec 2005

Keywords

  • Assembly factors
  • Cytochrome c oxidase
  • Metallation
  • Mitochondria

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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