Biological functions of multistable proteins

Kenneth W. Nickerson

doi:10.1016/0022-5193(73)90007-6

Biological functions of multistable proteins

Kenneth W. Nickerson

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Multistable proteins are defined as those that have available more than one most stable conformation. This capability requires a reversal of the most stable and metastable designations dependent upon environmental conditions. The concept of multistability is discussed with regard to enzyme maturation, hybrid vigor, metabolic temperature compensation, developmental gradients, membrane transport and the classical theory of allostery.

Original language	English (US)
Pages (from-to)	507-515
Number of pages	9
Journal	Journal of Theoretical Biology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/0022-5193(73)90007-6
State	Published - Aug 22 1973
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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10.1016/0022-5193(73)90007-6

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title = "Biological functions of multistable proteins",

abstract = "Multistable proteins are defined as those that have available more than one most stable conformation. This capability requires a reversal of the most stable and metastable designations dependent upon environmental conditions. The concept of multistability is discussed with regard to enzyme maturation, hybrid vigor, metabolic temperature compensation, developmental gradients, membrane transport and the classical theory of allostery.",

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AB - Multistable proteins are defined as those that have available more than one most stable conformation. This capability requires a reversal of the most stable and metastable designations dependent upon environmental conditions. The concept of multistability is discussed with regard to enzyme maturation, hybrid vigor, metabolic temperature compensation, developmental gradients, membrane transport and the classical theory of allostery.

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Biological functions of multistable proteins

Abstract

ASJC Scopus subject areas

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