Biological functions of multistable proteins

Kenneth W. Nickerson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Multistable proteins are defined as those that have available more than one most stable conformation. This capability requires a reversal of the most stable and metastable designations dependent upon environmental conditions. The concept of multistability is discussed with regard to enzyme maturation, hybrid vigor, metabolic temperature compensation, developmental gradients, membrane transport and the classical theory of allostery.

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
JournalJournal of Theoretical Biology
Issue number3
StatePublished - Aug 22 1973
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


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