Bioluminescence imaging

Ruxana T. Sadikot, Timothy S. Blackwell

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Bioluminescence refers to the process of visible light emission in living organisms. Bioluminescence imaging is a powerful methodology that has been developed over the last decade as a tool for molecular imaging of small laboratory animals, enabling the study of ongoing biological processes in vivo. This form of optical imaging is low cost and noninvasive and facilitates real-time analysis of disease processes at the molecular level in living organisms. In this article, we provide a brief introduction to bioluminescence imaging technology and discuss its applications in mouse models of lung inflammation/injury, bacterial pneumonia, and tumor growth and metastasis.

Original languageEnglish (US)
Pages (from-to)537-540
Number of pages4
JournalProceedings of the American Thoracic Society
Volume2
Issue number6
DOIs
StatePublished - 2005
Externally publishedYes

Keywords

  • Cancer
  • Endotoxin
  • Lung
  • Nuclear factor kappa B
  • Pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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