Biomarker discovery and clinical proteomics

Jerzy Silberring, Pawel Ciborowski

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

New biomarkers are urgently needed to accelerate efforts in developing new drugs and treatments of known diseases. New clinical and translational proteomics studies emerge almost every day. However, discovery of new diagnostic biomarkers lags behind because of variability at every step in proteomics studies (e.g., assembly of a cohort of patients, sample preparation and the nature of body fluids, selection of a profiling method and uniform protocols for data analysis). Quite often, the validation step that follows the discovery phase does not reach desired levels of sensitivity, specificity or reproducibility between laboratories. Mass spectrometry and gel-based methods do not provide enough throughput for screening thousands of clinical samples. Further development of protein arrays may address this issue. Despite many obstacles, proteomics delivers vast amounts of information useful for understanding the molecular mechanisms underlying diseases.

Original languageEnglish (US)
Pages (from-to)128-140
Number of pages13
JournalTrAC - Trends in Analytical Chemistry
Volume29
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Bioinformatics
  • Biomarker
  • Clinical
  • Electrophoresis
  • Immunodepletion
  • Liquid chromatography
  • Mass spectrometry
  • Protein array
  • Proteomics
  • Sample preparation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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