Biomarkers for early detection of colorectal cancer: The early detection research network, a framework for clinical translation

Robert S. Bresalier, William M. Grady, Sanford D. Markowitz, Hans Jørgen Nielsen, Surinder K. Batra, Paul D. Lampe

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Early detection by screening significantly reduces mortality from colorectal cancer, but 40% of guideline-eligible patients are not screened as recommended in the United States. Novel strategies to improve screening uptake overall and efforts to deploy best practices to underserved populations are a high priority for health care. This review focuses on existing biomarkers in practice and those in development with clinical relevance to early detection of colorectal neoplasia, with an emphasis on those developed by investigators of the NCI's Early Detection Research Network. Aberrantly methylated DNA markers (blood and stool), stool-based markers (including fecal immunochemical test-DNA), and a variety of blood-based marker assays in development (protein markers, glycoproteins including mucins, and cell-free DNA tests) are reviewed. Individual markers and biomarker panels, sample resources, and barriers to translating biomarkers to clinical practice are discussed.

Original languageEnglish (US)
Pages (from-to)2431-2440
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume29
Issue number12
DOIs
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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