Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation

Antonios P. Antoniadis, Peter Mortier, Ghassan Kassab, Gabriele Dubini, Nicolas Foin, Yoshinobu Murasato, Andreas A. Giannopoulos, Shengxian Tu, Kiyotaka Iwasaki, Yutaka Hikichi, Francesco Migliavacca, Claudio Chiastra, Jolanda J. Wentzel, Frank Gijsen, Johan H.C. Reiber, Peter Barlis, Patrick W. Serruys, Deepak L. Bhatt, Goran Stankovic, Elazer R. EdelmanGeorge D. Giannoglou, Yves Louvard, Yiannis S. Chatzizisis

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.

Original languageEnglish (US)
Article number2103
Pages (from-to)1281-1296
Number of pages16
JournalJACC: Cardiovascular Interventions
Volume8
Issue number10
DOIs
StatePublished - Aug 24 2015

Keywords

  • bifurcation
  • biomechanical stress
  • coronary artery disease
  • endothelial shear stress
  • stent(s)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Antoniadis, A. P., Mortier, P., Kassab, G., Dubini, G., Foin, N., Murasato, Y., Giannopoulos, A. A., Tu, S., Iwasaki, K., Hikichi, Y., Migliavacca, F., Chiastra, C., Wentzel, J. J., Gijsen, F., Reiber, J. H. C., Barlis, P., Serruys, P. W., Bhatt, D. L., Stankovic, G., ... Chatzizisis, Y. S. (2015). Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation. JACC: Cardiovascular Interventions, 8(10), 1281-1296. [2103]. https://doi.org/10.1016/j.jcin.2015.06.015