Biomedical production of implants by additive electro-chemical and physical processes

Paulo Bartolo, Jean Pierre Kruth, Jorge Silva, Gideon Levy, Ajay Malshe, Kamlakar Rajurkar, Mamoru Mitsuishi, Joaquim Ciurana, Ming Leu

Research output: Contribution to journalArticlepeer-review

282 Scopus citations


Biomanufacturing integrates life science and engineering fundamentals to produce biocompatible products enhancing the quality of life. The state-of-the-art of this rapidly evolving manufacturing sector is presented and discussed, in particular the additive electrical, chemical and physical processes currently being applied to produce synthetic and biological parts. This fabrication strategy is strongly material-dependent, so the main classes of biomaterials are detailed. It is explained the potential to process composite materials combining synthetic and biological materials, such as cells, proteins and growth factors, as well the interdependences between materials and processes. The techniques commonly used to increase the bioactivity of clinical implants and improve the interface characteristics between biological tissues and implants are also presented.

Original languageEnglish (US)
Pages (from-to)635-655
Number of pages21
JournalCIRP Annals - Manufacturing Technology
Issue number2
StatePublished - 2012


  • Additive manufacturing
  • Biomedical
  • Health care

ASJC Scopus subject areas

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering


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