Bionanotechnology and the future of glioma

Peter Chiarelli, Forrest Kievit, Miqin Zhang, Richard Ellenbogen

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Designer nanoscaled materials have the potential to revolutionize diagnosis and treatment for glioma. This review summarizes current progress in nanoparticle-based therapies for glioma treatment including targeting, drug delivery, gene delivery, and direct tumor ablation. Preclinical and current human clinical trials are discussed. Although progress in the field has been significant over the past decade, many successful strategies demonstrated in the laboratory have yet to be implemented in human clinical trials. Looking forward, we provide examples of combined treatment strategies, which harness the potential for nanoparticles to interact with their biochemical environment, and simultaneously with externally applied photons or magnetic fields. We present our notion of the "ideal" nanoparticle for glioma, a concept that may soon be realized.

Original languageEnglish (US)
Pages (from-to)S45-S58
JournalSurgical Neurology International
Volume6
Issue number2
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Drug delivery
  • Glioblastoma multiforme
  • Nanomedicine
  • Nanoparticle
  • Nanotechnology
  • Theranostic

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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