Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride

Bhavesh D. Kevadiya; Ghanshyam V. Joshi; Haresh M. Mody; Hari C. Bajaj

doi:10.1016/j.clay.2011.03.017

Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride

Bhavesh D. Kevadiya, Ghanshyam V. Joshi, Haresh M. Mody, Hari C. Bajaj

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.

Original language	English (US)
Pages (from-to)	364-367
Number of pages	4
Journal	Applied Clay Science
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/j.clay.2011.03.017
State	Published - Jun 2011
Externally published	Yes

Keywords

Controlled release
Hydrogel composite
Lidocaine hydrochloride
Montmorillonite

ASJC Scopus subject areas

Geology
Geochemistry and Petrology

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title = "Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride",

abstract = "The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.",

keywords = "Controlled release, Hydrogel composite, Lidocaine hydrochloride, Montmorillonite",

author = "Kevadiya, {Bhavesh D.} and Joshi, {Ghanshyam V.} and Mody, {Haresh M.} and Bajaj, {Hari C.}",

note = "Funding Information: We are thankful to the Council of Scientific and Industrial Research (CSIR) for funding under network project NWP 0010 ; to Dr. P. Bhatt (XRD), Mr. V. Agarwal (FTIR) and Mrs. Sheetal Patel (TGA) of the analytical section of the institute.",

year = "2011",

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AU - Kevadiya, Bhavesh D.

AU - Joshi, Ghanshyam V.

AU - Mody, Haresh M.

AU - Bajaj, Hari C.

N1 - Funding Information: We are thankful to the Council of Scientific and Industrial Research (CSIR) for funding under network project NWP 0010 ; to Dr. P. Bhatt (XRD), Mr. V. Agarwal (FTIR) and Mrs. Sheetal Patel (TGA) of the analytical section of the institute.

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N2 - The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.

AB - The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.

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KW - Hydrogel composite

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KW - Montmorillonite

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