Abstract
The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
Original language | English (US) |
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Pages (from-to) | 364-367 |
Number of pages | 4 |
Journal | Applied Clay Science |
Volume | 52 |
Issue number | 4 |
DOIs | |
State | Published - Jun 2011 |
Externally published | Yes |
Keywords
- Controlled release
- Hydrogel composite
- Lidocaine hydrochloride
- Montmorillonite
ASJC Scopus subject areas
- Geology
- Geochemistry and Petrology