Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride

Bhavesh D. Kevadiya, Ghanshyam V. Joshi, Haresh M. Mody, Hari C. Bajaj

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.

Original languageEnglish (US)
Pages (from-to)364-367
Number of pages4
JournalApplied Clay Science
Volume52
Issue number4
DOIs
StatePublished - Jun 2011

Keywords

  • Controlled release
  • Hydrogel composite
  • Lidocaine hydrochloride
  • Montmorillonite

ASJC Scopus subject areas

  • Geology
  • Geochemistry and Petrology

Fingerprint Dive into the research topics of 'Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride'. Together they form a unique fingerprint.

  • Cite this