Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride

Bhavesh D. Kevadiya; Ghanshyam V. Joshi; Haresh M. Mody; Hari C. Bajaj

doi:10.1016/j.clay.2011.03.017

Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride

Bhavesh D. Kevadiya, Ghanshyam V. Joshi, Haresh M. Mody, Hari C. Bajaj

Pharmacology & Experimental Neuroscience (PEN)

Research output: Contribution to journal › Article

62 Scopus citations

Abstract

The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.

Original language	English (US)
Pages (from-to)	364-367
Number of pages	4
Journal	Applied Clay Science
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/j.clay.2011.03.017
State	Published - Jun 2011

Keywords

Controlled release
Hydrogel composite
Lidocaine hydrochloride
Montmorillonite

ASJC Scopus subject areas

Geology
Geochemistry and Petrology

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Kevadiya, B. D., Joshi, G. V., Mody, H. M., & Bajaj, H. C. (2011). Biopolymer-clay hydrogel composites as drug carrier: Host-guest intercalation and in vitro release study of lidocaine hydrochloride. Applied Clay Science, 52(4), 364-367. https://doi.org/10.1016/j.clay.2011.03.017

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