Bioreducible polycations in nucleic acid delivery: Past, present, and future trends

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82 Scopus citations


Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes. This Feature Article provides an overview of the current status of research into the chemistry of bioreducible polycations and their use in nucleic acid delivery.

Original languageEnglish (US)
Pages (from-to)908-922
Number of pages15
JournalMacromolecular Bioscience
Issue number7
StatePublished - Jul 2014


  • bioreducible
  • disulfides
  • gene delivery
  • polycations
  • polyplexes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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