Biosensors employing ionic self-assembled multilayers adsorbed on long-period fiber gratings

Zhiyong Wang, J. R. Heflin, Kevin Van Cott, Rogers H. Stolen, Siddharth Ramachandran, Samir Ghalmi

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


We demonstrate that ionic self-assembled multilayers (ISAMs) adsorbed on long period gratings (LPGs) function effectively as biosensors using biotin-streptavidin as a demonstration bioconjugate pair. Biotin, streptavidin, and anti-streptavidin were deposited onto the ISAM-coated LPG sequentially, each inducing a measurable resonant wavelength shift of the LPG. Control experiments verified the specificity of the biosensor system. Furthermore, we demonstrate that ISAM coated turnaround point LPGs could serve as highly sensitive biosensors that exhibit a change in transmitted intensity rather than resonant wavelength. Experimental measurements confirm that ISAM-coated LPGs provide an attractive platform for building efficient and high-performance optical sensors.

Original languageEnglish (US)
Pages (from-to)618-623
Number of pages6
JournalSensors and Actuators, B: Chemical
Issue number2
StatePublished - Jun 4 2009
Externally publishedYes


  • Biosensors
  • Fiber gratings
  • Ionic self-assembled multilayers
  • Optical sensing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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