Biosynthesis, regulation, and engineering of natural products from Lysobacter

Huan Yue; Amanda Lynn Miller; Vimmy Khetrapal; Vishakha Jayaseker; Stephen Wright; Liangcheng Du

doi:10.1039/d1np00063b

Biosynthesis, regulation, and engineering of natural products from Lysobacter

Huan Yue, Amanda Lynn Miller, Vimmy Khetrapal, Vishakha Jayaseker, Stephen Wright, Liangcheng Du

Chemistry

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Covering: up to August 2021 Lysobacter is a genus of Gram-negative bacteria that was classified in 1987. Several Lysobacter species are emerging as new biocontrol agents for crop protection in agriculture. Lysobacter are prolific producers of new bioactive natural products that are largely underexplored. So far, several classes of structurally interesting and biologically active natural products have been isolated from Lysobacter. This article reviews the progress in Lysobacter natural product research over the past ten years, including molecular mechanisms for biosynthesis, regulation and mode of action, genome mining of cryptic biosynthetic gene clusters, and metabolic engineering using synthetic biology tools.

Original language	English (US)
Pages (from-to)	842-874
Number of pages	33
Journal	Natural Product Reports
Volume	39
Issue number	4
DOIs	https://doi.org/10.1039/d1np00063b
State	Published - Jan 24 2022

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1039/d1np00063b

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title = "Biosynthesis, regulation, and engineering of natural products from Lysobacter",

abstract = "Covering: up to August 2021 Lysobacter is a genus of Gram-negative bacteria that was classified in 1987. Several Lysobacter species are emerging as new biocontrol agents for crop protection in agriculture. Lysobacter are prolific producers of new bioactive natural products that are largely underexplored. So far, several classes of structurally interesting and biologically active natural products have been isolated from Lysobacter. This article reviews the progress in Lysobacter natural product research over the past ten years, including molecular mechanisms for biosynthesis, regulation and mode of action, genome mining of cryptic biosynthetic gene clusters, and metabolic engineering using synthetic biology tools.",

author = "Huan Yue and Miller, {Amanda Lynn} and Vimmy Khetrapal and Vishakha Jayaseker and Stephen Wright and Liangcheng Du",

note = "Funding Information: We want to thank all of our colleagues whose work is cited in the individual references of this review. The study was supported in part by University of Nebraska Collaboration Initiative Seed Grant, and the Nebraska Public Power District through the Nebraska Center for Energy Sciences Research at the University of Nebraska-Lincoln. Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

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AU - Yue, Huan

AU - Miller, Amanda Lynn

AU - Khetrapal, Vimmy

AU - Jayaseker, Vishakha

AU - Wright, Stephen

AU - Du, Liangcheng

N1 - Funding Information: We want to thank all of our colleagues whose work is cited in the individual references of this review. The study was supported in part by University of Nebraska Collaboration Initiative Seed Grant, and the Nebraska Public Power District through the Nebraska Center for Energy Sciences Research at the University of Nebraska-Lincoln. Publisher Copyright: © 2022 The Royal Society of Chemistry.

PY - 2022/1/24

Y1 - 2022/1/24

N2 - Covering: up to August 2021 Lysobacter is a genus of Gram-negative bacteria that was classified in 1987. Several Lysobacter species are emerging as new biocontrol agents for crop protection in agriculture. Lysobacter are prolific producers of new bioactive natural products that are largely underexplored. So far, several classes of structurally interesting and biologically active natural products have been isolated from Lysobacter. This article reviews the progress in Lysobacter natural product research over the past ten years, including molecular mechanisms for biosynthesis, regulation and mode of action, genome mining of cryptic biosynthetic gene clusters, and metabolic engineering using synthetic biology tools.

AB - Covering: up to August 2021 Lysobacter is a genus of Gram-negative bacteria that was classified in 1987. Several Lysobacter species are emerging as new biocontrol agents for crop protection in agriculture. Lysobacter are prolific producers of new bioactive natural products that are largely underexplored. So far, several classes of structurally interesting and biologically active natural products have been isolated from Lysobacter. This article reviews the progress in Lysobacter natural product research over the past ten years, including molecular mechanisms for biosynthesis, regulation and mode of action, genome mining of cryptic biosynthetic gene clusters, and metabolic engineering using synthetic biology tools.

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Biosynthesis, regulation, and engineering of natural products from Lysobacter

Abstract

ASJC Scopus subject areas

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