Biosynthesis, regulation, and engineering of natural products from Lysobacter

Huan Yue, Amanda Lynn Miller, Vimmy Khetrapal, Vishakha Jayaseker, Stephen Wright, Liangcheng Du

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Covering: up to August 2021 Lysobacter is a genus of Gram-negative bacteria that was classified in 1987. Several Lysobacter species are emerging as new biocontrol agents for crop protection in agriculture. Lysobacter are prolific producers of new bioactive natural products that are largely underexplored. So far, several classes of structurally interesting and biologically active natural products have been isolated from Lysobacter. This article reviews the progress in Lysobacter natural product research over the past ten years, including molecular mechanisms for biosynthesis, regulation and mode of action, genome mining of cryptic biosynthetic gene clusters, and metabolic engineering using synthetic biology tools.

Original languageEnglish (US)
Pages (from-to)842-874
Number of pages33
JournalNatural Product Reports
Volume39
Issue number4
DOIs
StatePublished - Jan 24 2022

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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