Biotin

Janos Zempleni; Subhashinee S.K. Wijeratne; Yousef I. Hassan

doi:10.1002/biof.8

Biotin

Janos Zempleni, Subhashinee S.K. Wijeratne, Yousef I. Hassan

Research output: Contribution to journal › Review article › peer-review

296 Scopus citations

Abstract

Biotin is a water-soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions of biotin. Proteins such as holocarboxylase synthetase, biotinidase, and the biotin transporters SMVT and MCT1 play crucial roles in biotin homeostasis, and these roles are reviewed here. Possible effects of inadequate biotin intake, drug interactions, and inborn errors of metabolism are discussed, including putative effects on birth defects.

Original language	English (US)
Pages (from-to)	36-46
Number of pages	11
Journal	BioFactors
Volume	35
Issue number	1
DOIs	https://doi.org/10.1002/biof.8
State	Published - Jan 2009

Keywords

Biotin
Biotinidase
Deficiency
Holocarboxylase synthetase
Metabolism
Transport

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Clinical Biochemistry

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10.1002/biof.8

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abstract = "Biotin is a water-soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions of biotin. Proteins such as holocarboxylase synthetase, biotinidase, and the biotin transporters SMVT and MCT1 play crucial roles in biotin homeostasis, and these roles are reviewed here. Possible effects of inadequate biotin intake, drug interactions, and inborn errors of metabolism are discussed, including putative effects on birth defects.",

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AU - Wijeratne, Subhashinee S.K.

AU - Hassan, Yousef I.

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AB - Biotin is a water-soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions of biotin. Proteins such as holocarboxylase synthetase, biotinidase, and the biotin transporters SMVT and MCT1 play crucial roles in biotin homeostasis, and these roles are reviewed here. Possible effects of inadequate biotin intake, drug interactions, and inborn errors of metabolism are discussed, including putative effects on birth defects.

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KW - Biotinidase

KW - Deficiency

KW - Holocarboxylase synthetase

KW - Metabolism

KW - Transport

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Biotin

Abstract

Keywords

ASJC Scopus subject areas

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