Abstract
The novel bifunctional bisalkaloids have been developed as highly efficient catalysts for the asymmetric conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes with low catalyst loading (1 mol %) at ambient temperature, providing the products with excellent enantioselectivities (up to 97% ee).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10186-10194 |
| Number of pages | 9 |
| Journal | Tetrahedron |
| Volume | 67 |
| Issue number | 52 |
| DOIs | |
| State | Published - Dec 30 2011 |
Keywords
- Baclofen
- Bifinctional
- Biscinchona alkaloids
- Conjugate addition
- Nitroalkenes
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Li, F., Li, Y. Z., Jia, Z. S., Xu, M. H., Tian, P., & Lin, G. Q. (2011). Biscinchona alkaloids as highly efficient bifunctional organocatalysts for the asymmetric conjugate addition of malonates to nitroalkenes at ambient temperature. Tetrahedron, 67(52), 10186-10194. https://doi.org/10.1016/j.tet.2011.08.070