Abstract
The novel bifunctional bisalkaloids have been developed as highly efficient catalysts for the asymmetric conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes with low catalyst loading (1 mol %) at ambient temperature, providing the products with excellent enantioselectivities (up to 97% ee).
Original language | English (US) |
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Pages (from-to) | 10186-10194 |
Number of pages | 9 |
Journal | Tetrahedron |
Volume | 67 |
Issue number | 52 |
DOIs | |
State | Published - Dec 30 2011 |
Externally published | Yes |
Keywords
- Baclofen
- Bifinctional
- Biscinchona alkaloids
- Conjugate addition
- Nitroalkenes
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry