TY - JOUR
T1 - Block ionomer complex micelles with cross-linked cores for drug delivery
AU - Kim, Jong Oh
AU - Nukolova, Nataliya V.
AU - Oberoi, Hardeep S.
AU - Kabanov, Alexander V.
AU - Bronich, Tatiana K.
N1 - Funding Information:
1 The text was submitted by the authors in English. 2This work was supported by the grants from U.S.A. National Institute of Health CA116590 (T.B.), National Science Founda tion DMR 0513699 (A.V.K. and T.B.) and Department of Defense USAMRMC 06108004 (A.V.K.).
PY - 2009/6
Y1 - 2009/6
N2 - Soft polymeric nanomaterials were synthesized by template-assisted method involving condensation of the poly(ethylene oxide)-b-polycarboxylate anions by metal ions into core-shell block ionomer complex micelles followed by chemical cross-linking of the polyion chains in the micelle cores. The resulting materials represent nanogels and are capable of swelling in a pH-dependent manner. The structural determinants that guide the self-assembly of the initial micelle templates and the swelling behavior of the cross-linked micelles include the block ionomer structure, the chemical nature of metal ions, the structure of the cross-links and the degree of cross-linking. The application of these materials for loading and release of a drug, cisplatin, is evaluated. These cross-linked block ionomer micelles have promise for delivery of pharmaceutical agents.
AB - Soft polymeric nanomaterials were synthesized by template-assisted method involving condensation of the poly(ethylene oxide)-b-polycarboxylate anions by metal ions into core-shell block ionomer complex micelles followed by chemical cross-linking of the polyion chains in the micelle cores. The resulting materials represent nanogels and are capable of swelling in a pH-dependent manner. The structural determinants that guide the self-assembly of the initial micelle templates and the swelling behavior of the cross-linked micelles include the block ionomer structure, the chemical nature of metal ions, the structure of the cross-links and the degree of cross-linking. The application of these materials for loading and release of a drug, cisplatin, is evaluated. These cross-linked block ionomer micelles have promise for delivery of pharmaceutical agents.
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U2 - 10.1134/S0965545X09060169
DO - 10.1134/S0965545X09060169
M3 - Article
C2 - 21127731
AN - SCOPUS:67849103508
SN - 0965-545X
VL - 51
SP - 708
EP - 718
JO - Polymer Science - Series A
JF - Polymer Science - Series A
IS - 6
ER -