TY - JOUR
T1 - Block ionomer complexes as prospective nanocontainers for drug delivery
AU - Oh, Kyung T.
AU - Bronich, Tatiana K.
AU - Bromberg, Lev
AU - Hatton, T. Alan
AU - Kabanov, Alexander V.
N1 - Funding Information:
This work was in past supported by NSF DMR awards (0071682 and 0513699) to A.V.K. K.T.O. has been supported by UNMC Fellowship. Authors would like to thank Sudhir Chakravarthi (UNMC) and Chris Olsen (UNMC) for the assistance in the use of the HPLC and the temperature-dependent UV spectrometer.
PY - 2006/9/28
Y1 - 2006/9/28
N2 - Nanosized environmentally responsive materials are of special interest for various applications, including drug delivery. Block ionomer complexes (BIC) composed of graft-comb copolymers of Pluronic and poly(acrylic acid) (Pluronic-PAA) and a model cationic surfactant, hexadecyltrimethylammonium bromide (HTAB), were synthesized by mixing the polymer and surfactant in aqueous media. According to TEM, the resulting BIC represented spherical particles of nanoscale size (50 to 100 nm). The stability of the BIC in the aqueous dispersion depended on the lengths of the hydrophilic poly(ethylene oxide) and hydrophobic poly(propylene oxide) chains in Pluronic molecules as well as on the surface charge of the resulting complexes. The latter was controlled by changing the ratio of the Pluronic-PAA and HTAB in the BIC and by changing the pH due to reversible ionization of the PAA chains. The acidification of the media below pH 6.0 resulted in the appearance of a strong positive charge on the BIC, which in the intracellular environment can trigger interaction of such BIC with the cell membranes. An efficient solubilization of a model hydrophobic molecule, Sudan III, and a drug, Etoposide, in such BIC was demonstrated with the loading capacities of about 6 to 15% by weight of the dispersed complex. Overall, these BIC wield a promise as environmentally responsive nanocarriers for pharmaceuticals.
AB - Nanosized environmentally responsive materials are of special interest for various applications, including drug delivery. Block ionomer complexes (BIC) composed of graft-comb copolymers of Pluronic and poly(acrylic acid) (Pluronic-PAA) and a model cationic surfactant, hexadecyltrimethylammonium bromide (HTAB), were synthesized by mixing the polymer and surfactant in aqueous media. According to TEM, the resulting BIC represented spherical particles of nanoscale size (50 to 100 nm). The stability of the BIC in the aqueous dispersion depended on the lengths of the hydrophilic poly(ethylene oxide) and hydrophobic poly(propylene oxide) chains in Pluronic molecules as well as on the surface charge of the resulting complexes. The latter was controlled by changing the ratio of the Pluronic-PAA and HTAB in the BIC and by changing the pH due to reversible ionization of the PAA chains. The acidification of the media below pH 6.0 resulted in the appearance of a strong positive charge on the BIC, which in the intracellular environment can trigger interaction of such BIC with the cell membranes. An efficient solubilization of a model hydrophobic molecule, Sudan III, and a drug, Etoposide, in such BIC was demonstrated with the loading capacities of about 6 to 15% by weight of the dispersed complex. Overall, these BIC wield a promise as environmentally responsive nanocarriers for pharmaceuticals.
KW - Block ionomer complex
KW - Drug delivery
KW - Nanomedicine
KW - Pluronic
KW - Solubilization
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U2 - 10.1016/j.jconrel.2006.06.030
DO - 10.1016/j.jconrel.2006.06.030
M3 - Article
C2 - 16919349
AN - SCOPUS:33748938527
SN - 0168-3659
VL - 115
SP - 9
EP - 17
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -