Blood-Brain Barrier Damage in the Context of HIV Infection and Drug Abuse

Honghong Yao, Yun Gao, Shilpa Buch

Research output: Chapter in Book/Report/Conference proceedingChapter


Human immunodeficiency virus (HIV) infections and intravenous drug use (IVDU) are two linked global health crises since needle sharing is a well-recognized mode of HIV transmission. While HIV-1 infection is the leading cause of death among Americans 25-44 yr old, injection drug use now accounts for about one-third of all new US AIDS cases reported each year. Drug abuse has been suggested to worsen HIV-associated central nervous system (CNS) disease via unknown mechanisms. The brain is a target organ for both, cocaine and HIV-1. Although highly active antiretroviral therapy (HAART) has diminished the incidence of HIV-1-associated dementia, milder forms of neurological disease do persist. Increased survival rates resulting from antiretroviral treatment have led to an increase in the prevalence of HIV-associated neurological disorders (HAND). The basis of HAND however, remains poorly understood.

Original languageEnglish (US)
Title of host publicationThe Blood-Brain Barrier in Health and Disease
Subtitle of host publicationVolume 2: Pathophysiology and Pathology
PublisherCRC Press
Number of pages17
ISBN (Electronic)9781498727099
ISBN (Print)9781498727082
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • General Neuroscience


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