Blood pressure effects of thyrotropin-releasing hormone and epinephrine in anaphylactic shock

Robert L. Muelleman, John P. Pribble, Joseph A. Salomone

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

To compare the effects of a single dose of thyrotropin-releasing hormone (TRH), epinephrine, and control (normal saline) on mean arterial pressure (MAP) and survival over a one-hour observation period, we carried out a randomized, blinded study using a rabbit model of anaphylaxis. Epinephrine resulted in an increased MAP over normal saline and TRH at one minute after treatment (P < .001). TRH resulted in an increased MAP over normal saline at two minutes (P < .017) and over epinephrine at four minutes (P < .011) after treatment. No differences in MAP were detected beyond four minutes after treatment. There was no difference in survival between treated and control animals (α < .168). Although no difference in survival existed, TRH had a slower onset, but more sustained effect on MAP than did epinephrine and normal saline.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalAnnals of emergency medicine
Volume17
Issue number4
DOIs
StatePublished - Apr 1988

Keywords

  • anaphylactic
  • epinepherine
  • shock
  • thyrotropi-releasing hormone

ASJC Scopus subject areas

  • Emergency Medicine

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