TY - JOUR
T1 - Blood pressure values and hypotension management in extremely preterm infants
T2 - a multi-center study
AU - Preterm Erythropoietin Neuroprotection (PENUT) Trial Investigators
AU - Peeples, Eric S.
AU - Comstock, Bryan A.
AU - Heagerty, Patrick J.
AU - Juul, Sandra E.
AU - Comstock, Bryan A.
AU - Heagerty, Patrick J.
AU - Juul, Sandra E.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/9
Y1 - 2022/9
N2 - Objective: To describe high/low daily blood pressures (BP) and variability in BP management with vasoactive infusions (VI) and/or hydrocortisone (HC) in extremely preterm infants. Study design: Analysis of data from 24–27 weeks’ gestation infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Daily high/low BPs, the use of VI and/or HC, and adverse outcomes were compared descriptively and using regression models. Results: 936 infants were included; 64% untreated, 20% VI, 3% HC, and 13% VI + HC. BP ranges are described for the 602 untreated infants. Considerable inter- and intra-center variability was demonstrated in the rate of VI and/or HC use and the lowest BP on the day of VI or HC initiation. Conclusions: Despite published expert opinion guidance regarding BP management in extremely preterm infants, our results suggest a continued lack of consensus result in both inter- and intra-center variability in practice. Well-designed studies in the field are urgently needed.
AB - Objective: To describe high/low daily blood pressures (BP) and variability in BP management with vasoactive infusions (VI) and/or hydrocortisone (HC) in extremely preterm infants. Study design: Analysis of data from 24–27 weeks’ gestation infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Daily high/low BPs, the use of VI and/or HC, and adverse outcomes were compared descriptively and using regression models. Results: 936 infants were included; 64% untreated, 20% VI, 3% HC, and 13% VI + HC. BP ranges are described for the 602 untreated infants. Considerable inter- and intra-center variability was demonstrated in the rate of VI and/or HC use and the lowest BP on the day of VI or HC initiation. Conclusions: Despite published expert opinion guidance regarding BP management in extremely preterm infants, our results suggest a continued lack of consensus result in both inter- and intra-center variability in practice. Well-designed studies in the field are urgently needed.
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U2 - 10.1038/s41372-022-01425-2
DO - 10.1038/s41372-022-01425-2
M3 - Article
C2 - 35715600
AN - SCOPUS:85133711632
SN - 0743-8346
VL - 42
SP - 1169
EP - 1175
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 9
ER -