Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: Implications for ischemic cardiovascular disease

Akm Khyrul Wara, Kevin Croce, Shi Yin Foo, Xinghui Sun, Basak Icli, Yevgenia Tesmenitsky, Fehim Esen, Anthony Rosenzweig, Mark W. Feinberg

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Clinical studies using bone marrow-derived proangiogenic cells (PACs) have demonstrated modest improvements of function and/or perfusion of ischemic myocardium or skeletal muscle. Because the identities of these PACs and their functional ability to promote neovascularization remain poorly understood, it is possible that a subset of robust PACs exists but is obscured by the heterogeneous nature of this cell population. Herein, we found that common myeloid progenitors (CMPs) and granulocyte-macrophage progenitors (GMPs) preferentially differentiate into PACs compared with megakaryocyte-erythrocyte progenitors, hematopoietic stem cells, and common lymphoid progenitors. In vivo hindlimb ischemia studies and Matrigel plug assays verified the enhanced neovascularization properties uniquely associated with PACs derived from CMPs and GMPs. Taken together, these observations identify CMPs and GMPs as key bone marrow progenitors for optimal PAC function in vitro and in vivo and provide a foundation for novel therapeutic approaches to modulate angiogenesis.

Original languageEnglish (US)
Pages (from-to)6461-6464
Number of pages4
JournalBlood
Volume118
Issue number24
DOIs
StatePublished - Dec 8 2011

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Wara, A. K., Croce, K., Foo, S. Y., Sun, X., Icli, B., Tesmenitsky, Y., Esen, F., Rosenzweig, A., & Feinberg, M. W. (2011). Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: Implications for ischemic cardiovascular disease. Blood, 118(24), 6461-6464. https://doi.org/10.1182/blood-2011-06-363457