Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice

Yanzhi Liu, Zhenshan Jia, Mohammed P. Akhter, Xiang Gao, Xiaobei Wang, Xiaoyan Wang, Gang Zhao, Xin Wei, You Zhou, Xiuli Wang, Curtis W. Hartman, Edward V. Fehringer, Liao Cui, Dong Wang

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Delayed fracture union is a significant clinical challenge in orthopedic practice. There are few non-surgical therapeutic options for this pathology. To address this challenge, we have developed a bone-targeting liposome (BTL) formulation of salvianic acid A (SAA), a potent bone anabolic agent, for improved treatment of delayed fracture union. Using pyrophosphorylated cholesterol as the targeting ligand, the liposome formulation (SAA-BTL) has demonstrated strong affinity to hydroxyapatite in vitro, and to bones in vivo. Locally administered SAA-BTL was found to significantly improve fracture callus formation and micro-architecture with accelerated mineralization rate in callus when compared to the dose equivalent SAA, non-targeting SAA liposome (SAA-NTL) or no treatment on a prednisone-induced delayed fracture union mouse model. Biomechanical analyses further validated the potent therapeutic efficacy of SAA-BTL. These results support SAA-BTL formulation, as a promising therapeutic candidate, to be further developed into an effective and safe clinical treatment for delayed bone fracture union.

Original languageEnglish (US)
Pages (from-to)2271-2282
Number of pages12
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number7
StatePublished - Oct 2018


  • Bone-targeting
  • Delayed fracture union
  • Fracture
  • Liposome
  • Salvianic acid A

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • General Materials Science
  • Pharmaceutical Science


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