Bone-targeting macromolecular therapeutics

Dong Wang, Scott C. Miller, Pavla Kopečková, Jindřich Kopeček

Research output: Contribution to journalReview articlepeer-review

151 Scopus citations

Abstract

Musculoskeletal diseases such as osteoporosis are recognized as major public health problems worldwide. Many novel therapeutic agents have been identified for the treatment of these diseases. However, the majority of them are not specific to hard tissue, resulting significant toxicity. Bone-targeting drug delivery systems based on water-soluble polymers can specifically direct candidate drugs to bone thereby reducing side effects due to non-specific tissue interactions. Incorporation of a targeting moiety, a drug release mechanism, drug selection and optimization of the polymer carrier are all essential elements in the development of bone-targeting macromolecular therapeutics. Successful clinical application of this approach can significantly contribute to the development of treatments for many musculoskeletal diseases.

Original languageEnglish (US)
Pages (from-to)1049-1076
Number of pages28
JournalAdvanced Drug Delivery Reviews
Volume57
Issue number7
DOIs
StatePublished - May 25 2005

Keywords

  • Bone-targeting
  • Cancer bone metastasis
  • Cathepsin K
  • Drug delivery
  • HPMA copolymer
  • Hydroxyapatite
  • Metalloproteinases (MMPs)
  • Osteoporosis
  • Polyethylene glycol (PEG)
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Pharmaceutical Science

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