Bovine herpesvirus 1 regulatory proteins are detected in trigeminal ganglionic neurons during the early stages of stress-induced escape from latency

Insun Kook, Alan Doster, Clinton Jones

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Bovine herpesvirus 1 (BHV-1) establishes latency in sensory neurons. The synthetic corticosteroid dexamethasone consistently induces reactivation from latency. Within 90 min after latently infected calves are treated with dexamethasone, two BHV-1 regulatory proteins, BHV-1-infected cell protein 0 (bICP0) and viral protein 16 (VP16), are expressed in the same neuron. In this study, we demonstrate that VP16 and bICP0 can be detected at 22 and 33 min after dexamethasone (DEX) treatment of latently infected calves. However, we were unable to discern whether VP16 or bICP0 was expressed at early times after reactivation. VP16+ neurons consistently express the glucocorticoid receptor suggesting corticosteroid-mediated activation of its receptor rapidly stimulates reactivation from latency.

Original languageEnglish (US)
Pages (from-to)585-591
Number of pages7
JournalJournal of neurovirology
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2015

Keywords

  • Bovine herpesvirus 1
  • ICP0
  • Stress-induced reactivation from latency
  • VP16

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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