TY - JOUR
T1 - Bovine herpesvirus type 1 (BoHV-1) anterograde neuronal transport from trigeminal ganglia to nose and eye requires glycoprotein E
AU - Brum, Mario C.S.
AU - Coats, Charles
AU - Sangena, Rajkumari B.
AU - Doster, Allan
AU - Jones, Clinton
AU - Chowdhury, Shafiqul I.
PY - 2009
Y1 - 2009
N2 - The requirement of bovine herpesvirus type 1 (BoHV-1) envelope protein gE (Us8 homolog) for establishment of latency and reactivation in trigeminal ganglia (TG) was examined. Although BHV-1 gE-rescued and gE-deleted viruses were isolated from nasal or ocular swabs during primary infection, only the gE-rescued virus was isolated following dexamethasone-induced reactivation. Furthermore, gC protein expression, which requires viral DNA replication for its expression, was detected in TG of calves infected with either virus following reactivation. These studies suggest that gE is required for anterograde transport of BoHV-1 from neuronal cell bodies in the TG to their nerve processes.
AB - The requirement of bovine herpesvirus type 1 (BoHV-1) envelope protein gE (Us8 homolog) for establishment of latency and reactivation in trigeminal ganglia (TG) was examined. Although BHV-1 gE-rescued and gE-deleted viruses were isolated from nasal or ocular swabs during primary infection, only the gE-rescued virus was isolated following dexamethasone-induced reactivation. Furthermore, gC protein expression, which requires viral DNA replication for its expression, was detected in TG of calves infected with either virus following reactivation. These studies suggest that gE is required for anterograde transport of BoHV-1 from neuronal cell bodies in the TG to their nerve processes.
KW - Anterograde transport
KW - BoHV-1
KW - Glycoprotein E
KW - Reactivation from latency
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U2 - 10.1080/13550280802549605
DO - 10.1080/13550280802549605
M3 - Article
C2 - 19115127
AN - SCOPUS:67650318973
SN - 1355-0284
VL - 15
SP - 196
EP - 201
JO - Journal of neurovirology
JF - Journal of neurovirology
IS - 2
ER -