Brain mechanical imaging (BMI)

Shadi F. Othman, Thomas Boulet, Huihui Xu, Matthew L. Kelso

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Multiple brain imaging techniques have been introduced, with structural imaging playing a role in acute disease diagnosis and functional imaging providing valuable information on the recovery mechanisms. However, current diagnostic brain imaging techniques have limitations since the imaging modalities differ in sensitivities to various brain abnormalities, limiting their utility for diagnosis. To better understand the pathology of different brain diseases, there is a need to develop an effective and sensitive imaging marker which is easily translatable to clinical settings. As a non-invasive imaging technique, magnetic resonance elastography (MRE) is based on synchronizing a mechanical actuator with a phase contrast imaging pulse sequence and measures tissue strain generated by sonic cyclic displacement. In this paper, we applied microscopic MRE (μMRE) as a diagnostic marker for characterizing different central nervous system disease models. While no single brain imaging modality can fully address the pathologies of different diseases, mechanical markers are proven to be effective in detecting different classes of brain diseases. This work aimed at: (1) designing, implementing, and testing an innovative actuation system for future μMRE applications, using a bite bar and rotating nose cone, to overcome the challenge of brain MRE - the brain is entirely encased by the skull, making wave generation and propagation inside complicated and demanding; (2) preliminary studies of using μMRE on different disease models, including multiple sclerosis (MS), traumatic brain injury (TBI), and medulloblastoma tumors.

Original languageEnglish (US)
Title of host publicationMechanics of Biological Systems and Materials - Proceedings of the 2012 Annual Conference on Experimental and Applied Mechanics
Number of pages6
StatePublished - 2013
Event2012 Annual Conference on Experimental and Applied Mechanics - Costa Mesa, CA, United States
Duration: Jun 11 2012Jun 14 2012

Publication series

NameConference Proceedings of the Society for Experimental Mechanics Series
ISSN (Print)2191-5644
ISSN (Electronic)2191-5652


Conference2012 Annual Conference on Experimental and Applied Mechanics
Country/TerritoryUnited States
CityCosta Mesa, CA


  • Brain model imaging
  • Elasticity imaging
  • MRE

ASJC Scopus subject areas

  • Engineering(all)
  • Computational Mechanics
  • Mechanical Engineering


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