Abstract
We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.
Original language | English (US) |
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Pages (from-to) | 69-77 |
Number of pages | 9 |
Journal | Ultrastructural Pathology |
Volume | 39 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2015 |
Keywords
- Alveolar soft part sarcoma
- Brain metastasis
- CD68
ASJC Scopus subject areas
- Structural Biology
- Pathology and Forensic Medicine