Abstract
Adenosine is a potent inhibitory modulator in the brain. It suppresses glutamatergic synaptic transmission and possibly acts as a brain endogenous neuroprotective agent. In this study we have examined the effects of a clinically used porcine brain tissue hydrolysate, Cerebrolysin(TM), on synaptic transmission in the CA1 area of rat hippocampal slices. A major effect of the drug at doses approximating those administered clinically to demented patients was a depression of synaptic transmission at the Schaffer collateral-commissural pathway in CA1. Detailed analysis showed that the inhibition is presynaptic and can be reduced by low doses of a specific blocker of adenosine A, receptors, 8-cyclopentyltheophylline. Because Cerebrolysin(TM) does not contain a detectable amount of adenosine, the effect on adenosine A1 receptors must be indirect, perhaps by release of the endogenous agonist. This action of Cerebrolysin(TM) is consistent with a putative neuroprotective action underlying its clinical usage.
Original language | English (US) |
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Pages (from-to) | 1194-1197 |
Number of pages | 4 |
Journal | Canadian journal of physiology and pharmacology |
Volume | 73 |
Issue number | 8 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
Keywords
- Adenosine
- Brain slices
- Cerebrolysin(TM)
- Hippocampus
- Synaptic transmission
ASJC Scopus subject areas
- Physiology
- Pharmacology
- Physiology (medical)