Abstract
BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.
Original language | English (US) |
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Pages (from-to) | 2711-2716 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 586 |
Issue number | 17 |
DOIs | |
State | Published - Aug 14 2012 |
Externally published | Yes |
Keywords
- BRCT domain
- DNA damage response
- Phosphopeptide binding
- Protein domain
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology