TY - JOUR
T1 - Breaking the species barrier
T2 - Use of SCID mouse-human chimeras for the study of human infectious diseases
AU - Davis, Paul H.
AU - Stanley, Samuel L.
PY - 2003/12
Y1 - 2003/12
N2 - Mouse-human chimeras have become a novel way to model the interactions between microbial pathogens and human cells, tissues or organs. Diseases studied with human xenografts in severe combined immunodeficient (SCID) mice include Pseudomonas aeruginosa infection in cystic fibrosis, group A streptococci and impetigo, bacillary and amoebic dysentery, and AIDS. In many cases, disease in the human xenograft appears to accurately reproduce the disease in humans, providing a powerful model for identifying virulence factors, host responses to infection and the effects of specific interventions on disease. In this review, we summarize recent studies that have used mouse-human chimeras to understand the pathophysiology of specific bacterial and protozoan infections.
AB - Mouse-human chimeras have become a novel way to model the interactions between microbial pathogens and human cells, tissues or organs. Diseases studied with human xenografts in severe combined immunodeficient (SCID) mice include Pseudomonas aeruginosa infection in cystic fibrosis, group A streptococci and impetigo, bacillary and amoebic dysentery, and AIDS. In many cases, disease in the human xenograft appears to accurately reproduce the disease in humans, providing a powerful model for identifying virulence factors, host responses to infection and the effects of specific interventions on disease. In this review, we summarize recent studies that have used mouse-human chimeras to understand the pathophysiology of specific bacterial and protozoan infections.
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U2 - 10.1046/j.1462-5822.2003.00321.x
DO - 10.1046/j.1462-5822.2003.00321.x
M3 - Review article
C2 - 14641171
AN - SCOPUS:0345602112
SN - 1462-5814
VL - 5
SP - 849
EP - 860
JO - Cellular Microbiology
JF - Cellular Microbiology
IS - 12
ER -