Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Robert Tanner Hagelstrom; James Ford; Gwendolyn M. Reiser; Marilu Nelson; Diane L. Pickering; Pamela A. Althof; Warren G. Sanger; Peter F. Coccia

doi:10.1002/pbc.25796

Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Robert Tanner Hagelstrom, James Ford, Gwendolyn M. Reiser, Marilu Nelson, Diane L. Pickering, Pamela A. Althof, Warren G. Sanger, Peter F. Coccia

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.

Original language	English (US)
Pages (from-to)	544-546
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	63
Issue number	3
DOIs	https://doi.org/10.1002/pbc.25796
State	Published - Mar 1 2016

Keywords

B-cell lymphoblastic lymphoma
Cowden syndrome
Male breast cancer
PTEN

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.25796

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title = "Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome",

abstract = "Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.",

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AU - Ford, James

AU - Reiser, Gwendolyn M.

AU - Nelson, Marilu

AU - Pickering, Diane L.

AU - Althof, Pamela A.

AU - Sanger, Warren G.

AU - Coccia, Peter F.

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AB - Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.

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Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Abstract

Keywords

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