TY - GEN
T1 - Breast cancer subtypes
T2 - Two decades of journey from cell culture to patients
AU - Zhao, Xiangshan
AU - Gurumurthy, Channabasavaiah B
AU - Malhotra, Gautam
AU - Mirza, Sameer
AU - Mohibi, Shakur
AU - Bele, Aditya
AU - Quinn, Meghan G.
AU - Band, Hamid
AU - Band, Vimla
N1 - Funding Information:
The authors thank the past and present members of their laboratories that have contributed to work published from our laboratories. Work in our laboratories was supported by the NIH Grants R01CA096844 and R01CA 144027 (VB), and R01CA099163, R01CA116552, R01CA105489, and R01CA087986 (HB) and department of defense breast cancer program W81XWH-07-1-0351 and W81XWH-11-1-0171 (VB), and W81XWH-11-1-0166 (HB) and Eppley Cancer Center Grant.
PY - 2011
Y1 - 2011
N2 - Recent molecular profiling has identified six major subtypes of breast cancers that exhibit different survival outcomes for patients. To address the origin of different subtypes of breast cancers, we have now identified, isolated, and immortalized (using hTERT) mammary stem/progenitor cells which maintain their stem/progenitor properties even after immortalization. Our decade long research has shown that these stem/progenitor cells are highly susceptible to oncogenesis. Given the emerging evidence that stem/progenitor cells are precursors of cancers and that distinct subtypes of breast cancer have different survival outcome, these cellular models provide novel tools to understand the oncogenic process leading to various subtypes of breast cancers and for future development of novel therapeutic strategies to treat different subtypes of breast cancers.
AB - Recent molecular profiling has identified six major subtypes of breast cancers that exhibit different survival outcomes for patients. To address the origin of different subtypes of breast cancers, we have now identified, isolated, and immortalized (using hTERT) mammary stem/progenitor cells which maintain their stem/progenitor properties even after immortalization. Our decade long research has shown that these stem/progenitor cells are highly susceptible to oncogenesis. Given the emerging evidence that stem/progenitor cells are precursors of cancers and that distinct subtypes of breast cancer have different survival outcome, these cellular models provide novel tools to understand the oncogenic process leading to various subtypes of breast cancers and for future development of novel therapeutic strategies to treat different subtypes of breast cancers.
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U2 - 10.1007/978-1-4614-0254-1_11
DO - 10.1007/978-1-4614-0254-1_11
M3 - Conference contribution
C2 - 21901624
AN - SCOPUS:80053895338
SN - 9781461402534
T3 - Advances in Experimental Medicine and Biology
SP - 135
EP - 144
BT - Human Cell Transformation
A2 - Rhim, Johng
A2 - Kremer, Richard
ER -