Abstract
Recent large-scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11 928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
| Original language | English (US) |
|---|---|
| Article number | bgr214 |
| Pages (from-to) | 1862-1866 |
| Number of pages | 5 |
| Journal | Carcinogenesis |
| Volume | 32 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2011 |
ASJC Scopus subject areas
- Cancer Research
Fingerprint Dive into the research topics of 'Breast cancer susceptibility polymorphisms and endometrial cancer risk: A collaborative endometrial cancer study'. Together they form a unique fingerprint.
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Breast cancer susceptibility polymorphisms and endometrial cancer risk : A collaborative endometrial cancer study. / Healey, Catherine S.; Ahmed, Shahana; Webb, P.; Young, J.; McQuire, L.; Baron-Hay, S.; Bell, D.; Bonaventura, A.; Brand, A.; Braye, S.; Carter, J.; Chan, F.; Dalrymple, C.; Ferrier, A.; Gard, G.; Hacker, N.; Hogg, R.; Houghton, R.; Marsden, D.; McIlroy, K.; Otton, G.; Pather, S.; Proietto, A.; Robertson, G.; Scurry, J.; Sharma, R.; Wain, G.; Wong, F.; Armes, J.; Crandon, A.; Cummings, M.; Land, R.; Nicklin, J.; Perrin, L.; Obermair, A.; Ward, B.; Davy, M.; Dodd, T.; Miller, J.; Oehler, M.; Paramasivum, S.; Pierides, J.; Whitehead, F.; Blomfield, P.; Challis, D.; Neesham, D.; Pyman, J.; Quinn, M.; Rome, R.; Weitzer, M.; Brennan, B.; Hammond, I.; Leung, Y.; McCartney, A.; Stewart, C.; Thompson, J.; O'Brien, S.; Moore, S.; Ferguson, K.; Walsh, M.; Cicero, R.; Green, L.; Griffith, J.; Jackman, L.; Ranieri, B.; O'Brien, M.; Schultz, P.; Alexander, B.; Baxter, C.; Croy, H.; Fitzgerald, A.; Herron, E.; Hill, C.; Jones, M.; Maidens, J.; Marshall, A.; Martin, K.; Mayhew, J.; Minehan, E.; Roffe, D.; Shirley, H.; Steane, H.; Stenlake, A.; Ward, A.; Webb, S.; White, J.; O'Mara, Tracy A.; Ferguson, Kaltin; Lambrechts, Diether; Garcia-Dios, Diego A.; Vergote, Ignace; Amant, Frederic; Tomlinson, Ian; Adams, M.; Al-Samarraie, A.; Anwar, S.; Athavale, R.; Awad, S.; Bali, A.; Barnes, A.; Cawdell, G.; Chan, S.; Chin, K.; Cornes, P.; Crawford, M.; Cullimore, J.; Ghaem-Maghami, S.; Gornall, R.; Green, J.; Hall, M.; Harvey, M.; Hawe, J.; Head, A.; Herod, J.; Hingorani, M.; Hocking, M.; Holland, C.; Hollingsworth, T.; Hollingworth, J.; Ind, T.; Irvine, R.; Irwin, C.; Katesmark, M.; Kehoe, S.; Kheng-Chew, G.; Lankester, K.; Linder, A.; Luesley, D.; BLynch, C.; McFarlane, V.; Naik, R.; Nicholas, N.; Nugent, D.; Oates, S.; Oladipo, A.; Papadopoulos, A.; Pearson, S.; Radstone, D.; Raju, S.; Rathmell, A.; Redman, C.; Rymer, M.; Sarhanis, P.; Sparrow, G.; Stuart, N.; Sundar, S.; Thompson, A.; Tinkler, S.; Trent, S.; Tristram, A.; Walji, N.; Woolas, R.; Howarth, Kimberley; Gorman, Maggie; Hodgson, Shirley; Tomlinson, Ian; Yang, Hannah P.; Lissowska, Jolanta; Brinton, Louise A.; Chanock, Stephen; Garcia-Closas, Montserrat; Hall, Per; Liu, Jianjun; Shah, Mitul; Pharoah, Paul D.P.; Thompson, Deborah J.; Rebbeck, Timothy R.; Strom, Brian L.; Dunning, Alison M.; Easton, Douglas F.; Spurdle, Amanda B.
In: Carcinogenesis, Vol. 32, No. 12, bgr214, 12.2011, p. 1862-1866.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Breast cancer susceptibility polymorphisms and endometrial cancer risk
T2 - A collaborative endometrial cancer study
AU - Healey, Catherine S.
AU - Ahmed, Shahana
AU - Webb, P.
AU - Young, J.
AU - McQuire, L.
AU - Baron-Hay, S.
AU - Bell, D.
AU - Bonaventura, A.
AU - Brand, A.
AU - Braye, S.
AU - Carter, J.
AU - Chan, F.
AU - Dalrymple, C.
AU - Ferrier, A.
AU - Gard, G.
AU - Hacker, N.
AU - Hogg, R.
AU - Houghton, R.
AU - Marsden, D.
AU - McIlroy, K.
AU - Otton, G.
AU - Pather, S.
AU - Proietto, A.
AU - Robertson, G.
AU - Scurry, J.
AU - Sharma, R.
AU - Wain, G.
AU - Wong, F.
AU - Armes, J.
AU - Crandon, A.
AU - Cummings, M.
AU - Land, R.
AU - Nicklin, J.
AU - Perrin, L.
AU - Obermair, A.
AU - Ward, B.
AU - Davy, M.
AU - Dodd, T.
AU - Miller, J.
AU - Oehler, M.
AU - Paramasivum, S.
AU - Pierides, J.
AU - Whitehead, F.
AU - Blomfield, P.
AU - Challis, D.
AU - Neesham, D.
AU - Pyman, J.
AU - Quinn, M.
AU - Rome, R.
AU - Weitzer, M.
AU - Brennan, B.
AU - Hammond, I.
AU - Leung, Y.
AU - McCartney, A.
AU - Stewart, C.
AU - Thompson, J.
AU - O'Brien, S.
AU - Moore, S.
AU - Ferguson, K.
AU - Walsh, M.
AU - Cicero, R.
AU - Green, L.
AU - Griffith, J.
AU - Jackman, L.
AU - Ranieri, B.
AU - O'Brien, M.
AU - Schultz, P.
AU - Alexander, B.
AU - Baxter, C.
AU - Croy, H.
AU - Fitzgerald, A.
AU - Herron, E.
AU - Hill, C.
AU - Jones, M.
AU - Maidens, J.
AU - Marshall, A.
AU - Martin, K.
AU - Mayhew, J.
AU - Minehan, E.
AU - Roffe, D.
AU - Shirley, H.
AU - Steane, H.
AU - Stenlake, A.
AU - Ward, A.
AU - Webb, S.
AU - White, J.
AU - O'Mara, Tracy A.
AU - Ferguson, Kaltin
AU - Lambrechts, Diether
AU - Garcia-Dios, Diego A.
AU - Vergote, Ignace
AU - Amant, Frederic
AU - Tomlinson, Ian
AU - Adams, M.
AU - Al-Samarraie, A.
AU - Anwar, S.
AU - Athavale, R.
AU - Awad, S.
AU - Bali, A.
AU - Barnes, A.
AU - Cawdell, G.
AU - Chan, S.
AU - Chin, K.
AU - Cornes, P.
AU - Crawford, M.
AU - Cullimore, J.
AU - Ghaem-Maghami, S.
AU - Gornall, R.
AU - Green, J.
AU - Hall, M.
AU - Harvey, M.
AU - Hawe, J.
AU - Head, A.
AU - Herod, J.
AU - Hingorani, M.
AU - Hocking, M.
AU - Holland, C.
AU - Hollingsworth, T.
AU - Hollingworth, J.
AU - Ind, T.
AU - Irvine, R.
AU - Irwin, C.
AU - Katesmark, M.
AU - Kehoe, S.
AU - Kheng-Chew, G.
AU - Lankester, K.
AU - Linder, A.
AU - Luesley, D.
AU - BLynch, C.
AU - McFarlane, V.
AU - Naik, R.
AU - Nicholas, N.
AU - Nugent, D.
AU - Oates, S.
AU - Oladipo, A.
AU - Papadopoulos, A.
AU - Pearson, S.
AU - Radstone, D.
AU - Raju, S.
AU - Rathmell, A.
AU - Redman, C.
AU - Rymer, M.
AU - Sarhanis, P.
AU - Sparrow, G.
AU - Stuart, N.
AU - Sundar, S.
AU - Thompson, A.
AU - Tinkler, S.
AU - Trent, S.
AU - Tristram, A.
AU - Walji, N.
AU - Woolas, R.
AU - Howarth, Kimberley
AU - Gorman, Maggie
AU - Hodgson, Shirley
AU - Tomlinson, Ian
AU - Yang, Hannah P.
AU - Lissowska, Jolanta
AU - Brinton, Louise A.
AU - Chanock, Stephen
AU - Garcia-Closas, Montserrat
AU - Hall, Per
AU - Liu, Jianjun
AU - Shah, Mitul
AU - Pharoah, Paul D.P.
AU - Thompson, Deborah J.
AU - Rebbeck, Timothy R.
AU - Strom, Brian L.
AU - Dunning, Alison M.
AU - Easton, Douglas F.
AU - Spurdle, Amanda B.
N1 - Funding Information: The genotyping and analysis of this study, and the conduct of the SEARCH study, was funded by Cancer Research UK grants (C490/ A11021, C8197/A10123, C1287/A7497, C1287/A10118), BCC grant (2007NovPR17) and EU FP7 COGS (HEALTH–F2-2009–223175). A.M.D. was supported by Cancer Research UK grant (C8197/ A10865) and The Joseph Mitchell Trust. Funding Information: ANECS was supported by a project grants from the National Health and Medical Research Council (NHMRC) of Australia (ID #339435), The Cancer Council Queensland (ID #4196615) and Cancer Council Tasmania (ID #403031 and ID #457636). A.B.S. is supported by an NHMRC Senior Research Fellowship. T.M. is supported by an Australian Postgraduate Award, an Institute of Health and Biomedical Innovation PhD Top-Up and a Smart State PhD Award. Funding Information: LES was supported by the Verelst Foundation for Endometrial Cancer. Funding Information: NSECG was supported by funding from Cancer Research UK and the Oxford Comprehensive Biomedical Research Centre. Funding Information: PECS was funded by the intramural research program at the US National Cancer Institute, Division of Cancer Epidemiology and Genetics in the Hormonal and Reproductive Epidemiology Branch. Funding Information: SASBAC is supported by the Agency for Science, Technology and Research of Singapore (A*STAR). WISE was supported by a Public Health Service Grant (P01-CA77596).
PY - 2011/12
Y1 - 2011/12
N2 - Recent large-scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11 928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
AB - Recent large-scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11 928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
UR - http://www.scopus.com/inward/record.url?scp=81855183847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81855183847&partnerID=8YFLogxK
U2 - 10.1093/carcin/bgr214
DO - 10.1093/carcin/bgr214
M3 - Article
C2 - 21965274
AN - SCOPUS:81855183847
VL - 32
SP - 1862
EP - 1866
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 12
M1 - bgr214
ER -