TY - JOUR
T1 - Brn-3b
T2 - a POU domain gene expressed in a subset of retinal ganglion cells
AU - Xiang, Mengqing
AU - Zhou, Lijuan
AU - Peng, Y. W.
AU - Eddy, Roger L.
AU - Shows, Thomas B.
AU - Nathans, Jeremy
N1 - Funding Information:
We thank Dr. Clark Riley, Ms. Carol Davenport, and Ms. Janine Ptak for synthetic oligonucleotides; Dr. Keith Fry (Baylor College of Medicine) for the gift of monoclonal antibody AB5; and Ms. Jennifer Macke, Dr. Isabel Chiu, Dr. Randall Reed, and Dr. King-Wai Yau for helpful comments on the manuscript. This work was supported by the Howard Hughes Medical Institute. Y.-W. P. was supported by a National Institutes of Health grant (EY06837) to Dr. K.-W. Yau.
PY - 1993/10
Y1 - 1993/10
N2 - A search for POU domain transcription factors in human retina cDNA has led to the identification of Brn-3b, a class IV POU domain protein. Immunohistochemical experiments show that chicken, mouse, rabbit, monkey, and human retinas contain Brn-3b exclusively within a subpopulation of ganglion cells. In the adult mouse brain, Brn-3b is found only within cells in the deep layers of the superior colliculus, in the dorsal periaquaductal gray, and in a small cluster of cells in the brain stem near the area postrema. During the immediate postnatal period, cells containing Brn-3b are distributed in a number of regions within the brain stem and cerebellum. These data suggest that Brn-3b plays a role in determining and/or maintaining the identities of a small number of neurons, including a subset of visual system neurons.
AB - A search for POU domain transcription factors in human retina cDNA has led to the identification of Brn-3b, a class IV POU domain protein. Immunohistochemical experiments show that chicken, mouse, rabbit, monkey, and human retinas contain Brn-3b exclusively within a subpopulation of ganglion cells. In the adult mouse brain, Brn-3b is found only within cells in the deep layers of the superior colliculus, in the dorsal periaquaductal gray, and in a small cluster of cells in the brain stem near the area postrema. During the immediate postnatal period, cells containing Brn-3b are distributed in a number of regions within the brain stem and cerebellum. These data suggest that Brn-3b plays a role in determining and/or maintaining the identities of a small number of neurons, including a subset of visual system neurons.
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U2 - 10.1016/0896-6273(93)90079-7
DO - 10.1016/0896-6273(93)90079-7
M3 - Article
C2 - 7691107
AN - SCOPUS:0027439125
SN - 0896-6273
VL - 11
SP - 689
EP - 701
JO - Neuron
JF - Neuron
IS - 4
ER -