Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells

Mengqing Xiang, Lijuan Zhou, Y. W. Peng, Roger L. Eddy, Thomas B. Shows, Jeremy Nathans

Research output: Contribution to journalArticle

181 Scopus citations

Abstract

A search for POU domain transcription factors in human retina cDNA has led to the identification of Brn-3b, a class IV POU domain protein. Immunohistochemical experiments show that chicken, mouse, rabbit, monkey, and human retinas contain Brn-3b exclusively within a subpopulation of ganglion cells. In the adult mouse brain, Brn-3b is found only within cells in the deep layers of the superior colliculus, in the dorsal periaquaductal gray, and in a small cluster of cells in the brain stem near the area postrema. During the immediate postnatal period, cells containing Brn-3b are distributed in a number of regions within the brain stem and cerebellum. These data suggest that Brn-3b plays a role in determining and/or maintaining the identities of a small number of neurons, including a subset of visual system neurons.

Original languageEnglish (US)
Pages (from-to)689-701
Number of pages13
JournalNeuron
Volume11
Issue number4
DOIs
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Neuroscience(all)

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    Xiang, M., Zhou, L., Peng, Y. W., Eddy, R. L., Shows, T. B., & Nathans, J. (1993). Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron, 11(4), 689-701. https://doi.org/10.1016/0896-6273(93)90079-7