Bupropion and nicotine patch as smoking cessation aids in alcoholics

Kathleen M Grant, Stephanie Sinclair Kelley, Lynette M. Smith, Sangeeta Agrawal, James R. Meyer, Debra J. Romberger

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism. Participants (N = 58) were enrolled within 1 week of entry into alcohol treatment from community and Veterans Affairs Substance Use Disorder programs. All participants received nicotine patch and were invited to attend a smoking cessation lecture and group. Cigarette smoking and alcohol outcomes were measured at 6 months. Bupropion when added to nicotine patch did not improve smoking outcomes. One third of participants on bupropion reported discontinuing the drug during weeks 1-4. Participants reported cigarette outcomes with nicotine patch that are similar to those seen in the general population. All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes.

Original languageEnglish (US)
Pages (from-to)381-391
Number of pages11
Issue number5
StatePublished - Aug 2007


  • Alcoholism
  • Bupropion
  • Nicotine dependence
  • Nicotine replacement
  • Smoking cessation

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience


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