TY - JOUR
T1 - Burden and trajectory of multimorbidity in rheumatoid arthritis
T2 - A matched cohort study from 2006 to 2015
AU - England, Bryant R.
AU - Roul, Punyasha
AU - Yang, Yangyuna
AU - Sayles, Harlan
AU - Yu, Fang
AU - Michaud, Kaleb
AU - Xie, Fenglong
AU - Curtis, Jeffrey R.
AU - Mikuls, Ted R.
N1 - Funding Information:
Funding This work was supported by the Rheumatology Research Foundation Scientist Development Award (BRE), Great Plains IDeA-CTR Scholars Award (BRE) and Patient-Centered Outcomes Research Institute (JRC). TRM is supported by the NIH/NIGMS (U54GM115458) and NIAAA (R25AA020818).
Publisher Copyright:
©
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Objectives To compare the onset and trajectory of multimorbidity between individuals with and without rheumatoid arthritis (RA). Methods A matched, retrospective cohort study was completed in a large, US commercial insurance database (MarketScan) from 2006 to 2015. Using validated algorithms, patients with RA (overall and incident) were age-matched and sex-matched to patients without RA. Diagnostic codes for 44 preidentified chronic conditions were selected to determine the presence (≥2 conditions) and burden (count) of multimorbidity. Cross-sectional comparisons were completed using the overall RA cohort and conditional logistic and negative binomial regression models. Trajectories of multimorbidity were assessed within the incident RA subcohort using generalised estimating equations. Results The overall cohort (n=277 782) and incident subcohort (n=61 124) were female predominant (76.5%, 74.1%) with a mean age of 55.6 years and 54.5 years, respectively. The cross-sectional prevalence (OR 2.29, 95% CI 2.25 to 2.34) and burden (ratio of conditions 1.68, 95% CI 1.66 to 1.70) of multimorbidity were significantly higher in RA than non-RA in the overall cohort. Within the incident RA cohort, patients with RA had more chronic conditions than non-RA (β 1.13, 95% CI 1.10 to 1.17), and the rate of accruing chronic conditions was significantly higher in RA compared with non-RA (RA × follow-up year, β 0.21, 95% CI 0.20 to 0.21, p<0.001). Results were similar when including the pre-RA period and in several sensitivity analyses. Conclusions Multimorbidity is highly prevalent in RA and progresses more rapidly in patients with RA than in patients without RA during and immediately following RA onset. Therefore, multimorbidity should be aggressively identified and targeted early in the RA disease course.
AB - Objectives To compare the onset and trajectory of multimorbidity between individuals with and without rheumatoid arthritis (RA). Methods A matched, retrospective cohort study was completed in a large, US commercial insurance database (MarketScan) from 2006 to 2015. Using validated algorithms, patients with RA (overall and incident) were age-matched and sex-matched to patients without RA. Diagnostic codes for 44 preidentified chronic conditions were selected to determine the presence (≥2 conditions) and burden (count) of multimorbidity. Cross-sectional comparisons were completed using the overall RA cohort and conditional logistic and negative binomial regression models. Trajectories of multimorbidity were assessed within the incident RA subcohort using generalised estimating equations. Results The overall cohort (n=277 782) and incident subcohort (n=61 124) were female predominant (76.5%, 74.1%) with a mean age of 55.6 years and 54.5 years, respectively. The cross-sectional prevalence (OR 2.29, 95% CI 2.25 to 2.34) and burden (ratio of conditions 1.68, 95% CI 1.66 to 1.70) of multimorbidity were significantly higher in RA than non-RA in the overall cohort. Within the incident RA cohort, patients with RA had more chronic conditions than non-RA (β 1.13, 95% CI 1.10 to 1.17), and the rate of accruing chronic conditions was significantly higher in RA compared with non-RA (RA × follow-up year, β 0.21, 95% CI 0.20 to 0.21, p<0.001). Results were similar when including the pre-RA period and in several sensitivity analyses. Conclusions Multimorbidity is highly prevalent in RA and progresses more rapidly in patients with RA than in patients without RA during and immediately following RA onset. Therefore, multimorbidity should be aggressively identified and targeted early in the RA disease course.
KW - arthritis
KW - epidemiology
KW - health care
KW - outcome assessment
KW - rheumatoid
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U2 - 10.1136/annrheumdis-2020-218282
DO - 10.1136/annrheumdis-2020-218282
M3 - Article
C2 - 33032999
AN - SCOPUS:85092761492
SN - 0003-4967
VL - 80
SP - 286
EP - 292
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 3
ER -