Burrowing through the heterogeneity: Review of mouse models of PTCL-NOS

Christine E. Cutucache, Tyler A. Herek

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

Currently, there are 19 different peripheral T-cell lymphoma (PTCL) entities recognized by the World Health Organization; however, ~70% of PTCL diagnoses fall within one of three subtypes [i.e., peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), anaplastic large-cell lymphoma, and angioimmunoblastic T-cell lymphoma]. PTCL-NOS is a grouping of extra-thymic neoplasms that represent a challenging and heterogeneous subset of non-Hodgkin's lymphomas. Research into peripheral T-cell lymphomas has been cumbersome as the lack of defining cytogenetic, histological, and molecular features has stymied diagnosis and treatment of these diseases. Similarly, the lacks of genetically manipulated murine models that faithfully recapitulate disease characteristics were absent prior to the turn of the century. Herein, we review the literature concerning existing mouse models for PTLC-NOS, while paying particular attention to the etiology of this heterogeneous disease.

Original languageEnglish (US)
Article number206
JournalFrontiers in Oncology
Volume7
Issue numberSEP
DOIs
StatePublished - Sep 26 2016

Keywords

  • Genetically engineered
  • Mouse models
  • Neoplasms
  • PTCL-NOS
  • T-cell lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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