Butyrate induces sLex synthesis by stimulation of selective glycosyltransferase genes

Prakash Radhakrishnan, Paul V. Beum, Shuhua Tan, Pi Wan Cheng

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Sialyl Lewisx (sLex) is an important tumor-associated carbohydrate antigen present on the cell surface glycoconjugates involved in leukocyte migration and cancer metastasis. We report the formation of sLex epitope in butyrate-treated human pancreatic adenocarcinoma cells expressing MUC1 and core 2 N-acetylglucosaminyltransferase (C2GnT). Butyrate treatment stimulates not only the transgene but also a group of endogenous glycosyltransferase genes involved in the synthesis of sLex. Current finding raises a concern about the proposed use of butyrate as a cancer therapeutic agent.

Original languageEnglish (US)
Pages (from-to)457-462
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume359
Issue number3
DOIs
StatePublished - Aug 3 2007

Keywords

  • Butyrate
  • Glycosyltransferase
  • Pancreatic cancer
  • sLe

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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