Abstract
Sialyl Lewisx (sLex) is an important tumor-associated carbohydrate antigen present on the cell surface glycoconjugates involved in leukocyte migration and cancer metastasis. We report the formation of sLex epitope in butyrate-treated human pancreatic adenocarcinoma cells expressing MUC1 and core 2 N-acetylglucosaminyltransferase (C2GnT). Butyrate treatment stimulates not only the transgene but also a group of endogenous glycosyltransferase genes involved in the synthesis of sLex. Current finding raises a concern about the proposed use of butyrate as a cancer therapeutic agent.
Original language | English (US) |
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Pages (from-to) | 457-462 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 359 |
Issue number | 3 |
DOIs | |
State | Published - Aug 3 2007 |
Keywords
- Butyrate
- Glycosyltransferase
- Pancreatic cancer
- sLe
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology