Cadherin-mediated cellular signaling

Margaret J. Wheelock, Keith R. Johnson

Research output: Contribution to journalReview articlepeer-review

237 Scopus citations


Recent cadherin studies focusing on cellular signaling have shown that several pathways are activated by cadherin-mediated cell-cell contact. Cadherin-mediated contacts activate Rho family GTPases, regulate the availability of β-catenin to participate in Wnt signaling, and function in receptor tyrosine kinase signaling. Although different classical cadherins bind to the same cytosolic proteins via their cytoplasmic tails, one message that is clear from the recent literature is that downstream signals emanating from cadherin-mediated contacts are both cadherin-specific and cell-context-specific.

Original languageEnglish (US)
Pages (from-to)509-514
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number5
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Cell Biology


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