Cadherin switching

Margaret J. Wheelock, Yasushi Shintani, Masato Maeda, Yuri Fukumoto, Keith R. Johnson

Research output: Contribution to journalComment/debatepeer-review

689 Scopus citations


The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor and metastasize. At present, we understand some of the mechanisms that promote cadherin switching and some of the pathways downstream of this process that influence cell behavior. Specific cadherin family members influence growth-factor-receptor signaling and Rho GTPases to promote cell motility and invasion. In addition, p120-catenin probably plays multiple roles in cadherin switching, regulating Rho GTPases and stabilizing cadherins.

Original languageEnglish (US)
Pages (from-to)727-735
Number of pages9
JournalJournal of cell science
Issue number6
StatePublished - Mar 15 2008


  • Biology
  • Cadherin
  • Switching

ASJC Scopus subject areas

  • Cell Biology


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