Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis

Dimitrios P. Kontoyiannis, Russell E. Lewis, Barbara D. Alexander, Olivier Lortholary, Françoise Dromer, Krishan L. Gupta, George T. John, Ramon Del Busto, Goran B. Klintmalm, Jyoti Somani, G. Marshall Lyon, Kenneth Pursell, Valentina Stosor, Patricia Muňoz, Ajit P. Limaye, Andre C. Kalil, Timothy L. Pruett, Julia Garcia-Diaz, Atul Humar, Sally HoustonAndrew A. House, Dannah Wray, Susan Orloff, Lorraine A. Dowdy, Robert A. Fisher, Joseph Heitman, Nathaniel D. Albert, Marilyn M. Wagener, Nina Singh

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number2
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Kontoyiannis, D. P., Lewis, R. E., Alexander, B. D., Lortholary, O., Dromer, F., Gupta, K. L., John, G. T., Del Busto, R., Klintmalm, G. B., Somani, J., Lyon, G. M., Pursell, K., Stosor, V., Muňoz, P., Limaye, A. P., Kalil, A. C., Pruett, T. L., Garcia-Diaz, J., Humar, A., ... Singh, N. (2008). Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrobial Agents and Chemotherapy, 52(2), 735-738. https://doi.org/10.1128/AAC.00990-07