Can recombinant DNA technology provide useful vaccines against viruses which induce heart disease?

N. M. Chapman, S. Tracy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In the panoply of armaments against viral infections, both drugs and vaccines have been employed. Numerous vaccines have enjoyed spectacular success in either eradicating or controlling various viral diseases, whereas there are still few, effective anti-viral drugs. Coxsackie B viruses are agents of human inflammatory heart disease and may trigger events lending to a failing heart. We believe that enteroviral heart disease could be controlled or eradicated through the use of vaccines, in much the same manner as poliovirus-induced poliomyelitis has been controlled through vaccination. We present here preliminary data which deal with an approach to the development of enterovirus vaccines and the use of a chimeric coxsackievirus us B3 (CVB3) vaccine in a murine model of CVB3-induced inflammatory heart disease.

Original languageEnglish (US)
Pages (from-to)144-146
Number of pages3
JournalEuropean Heart Journal
Volume16
Issue numberSUPPL. O
DOIs
StatePublished - 1995

Keywords

  • Coxsackievirus B3
  • Enterovirus
  • Vaccines

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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