Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme

Steven S.L. Li; Yu Ching E. Pan; Farida S. Sharief; Mary Jo Evans; Ming Fong Lin; Gail M. Clinton; J. John Holbrook

doi:10.3109/07357908809077032

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme

Steven S.L. Li, Yu Ching E. Pan, Farida S. Sharief, Mary Jo Evans, Ming Fong Lin, Gail M. Clinton, J. John Holbrook

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.

Original language	English (US)
Pages (from-to)	93-101
Number of pages	9
Journal	Cancer Investigation
Volume	6
Issue number	1
DOIs	https://doi.org/10.3109/07357908809077032
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme",

abstract = "Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.",

author = "Li, {Steven S.L.} and Pan, {Yu Ching E.} and Sharief, {Farida S.} and {Jo Evans}, Mary and Lin, {Ming Fong} and Clinton, {Gail M.} and Holbrook, {J. John}",

year = "1988",

doi = "10.3109/07357908809077032",

language = "English (US)",

volume = "6",

pages = "93--101",

journal = "Cancer Investigation",

issn = "0735-7907",

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number = "1",

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TY - JOUR

T1 - Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme

AU - Li, Steven S.L.

AU - Pan, Yu Ching E.

AU - Sharief, Farida S.

AU - Jo Evans, Mary

AU - Lin, Ming Fong

AU - Clinton, Gail M.

AU - Holbrook, J. John

PY - 1988

Y1 - 1988

N2 - Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.

AB - Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.

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DO - 10.3109/07357908809077032

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AN - SCOPUS:0023886824

SN - 0735-7907

VL - 6

SP - 93

EP - 101

JO - Cancer Investigation

JF - Cancer Investigation

IS - 1

ER -

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme

Abstract

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